Micro-iodometric assay for penicillinase

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New Assay for Penicillinase and Some Results on Penicillinase Induction.

Imsande, John (Western Reserve University, Cleveland, Ohio). New assay for penicillinase and some results on penicillinase induction. J. Bacteriol. 89:1322-1327. 1965.-A rapid, sensitive, and reliable assay of penicillinase activity is described. Studies conducted on the induction of penicillinase, with use of the new assay, show that actinomycin D inhibits growth and the induced synthesis of p...

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Rapid fixed-time assay for penicillinase.

Many methods of assaying penicillinase activity have been devised (N. Citri and M. R. Pollock, Advan. Enzymol. 28:237, 1966; N. Citri, Methods Med. Res., 10:221, 1964; J. M. T. HamiltonMiller et al., J. Pharm. Pharmacol. 15:81, 1963; D. A. Wolfe and M. Hamberger, J. Lab. Clin. Med. 59:469, 1962). These have included colorimetric determinations of acid or alkali production, manometric techniques...

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ENZYME-LINKED IMMUNOSORBENT ASSAY OF NEOPTERIN USING PENICILLINASE AS LABEL

An enzyme-linked immunosorbent assay for neopterin using penicillinase as marker enzyme is reported here by polyclonal antibodies against neopterin conjugated to bovine serum albumin which were raised in rabbits. Immunoglobulin fractions were purified and coated on wells of microtiter plates. A chain heterology was introduced in neopterin derivative and conjugated to penicillinase. The assa...

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Iodometric assay method for beta-lactamase with various beta-lactam antibiotics as substrates.

The rapid fixed-time assay for penicillinase was modified for measuring beta-lactamase activity with twelve substrates, i.e., benzylpenicillin, ampicillin, cloxacillin, methicillin, carbenicillin, cefazolin, cephalothin, cephaloglycin, cephalexin, cephalosporin C, 7-aminocephalosporanic acid, and cefoxitin. The method depends upon the reduction of iodine by the hydrolyzed substrate. Determined ...

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DEVELOPMENT OF A SIMPLE AND SENSITIVE ENZYME- LINKED IMMUNOSORBENT ASSAY (ELISA) FOR CLINICAL MEASUREMENT OF TESTOSTERONE USING PENICILLINASE AS LABEL

An enzyme-linked immunosorbent assay using a homologous combination of antiserum raised against testosterone-3-0-carboxymethyloxime-bovine serum albumin (T-3-0-CMO-BSA ) and penicillinase-labelled T-3-0-CMO was developed. This assay was utilized to measure testosterone in serum samples of male and female subjects. The sensitivity of the assay is 50pg/well and the antibody developed crossrea...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1962

ISSN: 0006-2936

DOI: 10.1042/bj0830236